TB-500 is a thymosin beta-4 fragment supplied by Apex Laboratory as a high-purity research peptide intended strictly for in-vitro laboratory research and development applications.

Compound Overview

TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein involved in actin regulation and cell migration. TB-500 binds G-actin (monomeric actin) and promotes actin polymerization, which is central to cell motility, cytoskeletal organization, and tissue remodeling in research models.

Research Background & Published Literature

Thymosin Beta-4 and its active fragments have been extensively studied for their roles in wound repair models, angiogenesis, anti-inflammatory signaling, and cardiac tissue research. Published studies in journals including Annals of the New York Academy of Sciences and FASEB Journal have characterized its actin-binding properties and downstream signaling effects.

Researchers interested in the published literature surrounding this compound can explore the following peer-reviewed resources for additional context on its mechanism of action, signaling pathways, and experimental applications in controlled laboratory settings:

Technical Specifications

Product Name: TB-500
Classification: Thymosin Beta-4 Fragment
Structural Description: 43-amino acid peptide, synthetic fragment of Thymosin Beta-4
CAS Number: 77591-33-4
Molecular Weight: 4963.50 g/mol
Purity: ≥99% (verified by HPLC and Mass Spectrometry)
Physical Form: Lyophilized (freeze-dried) powder
Intended Use: In-vitro research use only — not for human consumption

Storage, Handling & Stability Guidelines

Store lyophilized TB-500 at -20°C for long-term stability. After reconstitution with bacteriostatic water, store at 2–8°C and use within 14 days. Aliquot to minimize freeze-thaw cycles.

Minimize time at ambient temperature during handling to preserve compound integrity.
Avoid moisture exposure by resealing vials promptly after each withdrawal.
Use appropriate personal protective equipment and follow your institution’s chemical safety protocols at all times.
Label all aliquots with the compound name, concentration, date of reconstitution, and operator initials for complete traceability.

Quality Assurance & Analytical Verification

Apex Laboratory applies a dual-verification quality protocol to every batch before it enters inventory. Each lot undergoes High-Performance Liquid Chromatography (HPLC) to confirm chromatographic purity and Mass Spectrometry (MS) to verify molecular identity and molecular weight. This two-step analytical process ensures that the material you receive meets our ≥99% purity standard with confirmed molecular integrity. Certificates of Analysis documenting these results are available upon request for your internal quality records.

Frequently Asked Questions

What is the relationship between TB-500 and Thymosin Beta-4?

TB-500 is a synthetic peptide that corresponds to the active actin-binding region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein. TB-500 retains the key actin-sequestering properties of the full-length protein.

What is the molecular weight of TB-500?

TB-500 has a molecular weight of approximately 4963.50 g/mol (CAS 77591-33-4).

Is this product approved for human use?

No. All compounds sold by Apex Laboratory are classified as chemical research reagents intended strictly for in-vitro laboratory research. They are not approved for human consumption, veterinary use, or any therapeutic application. Purchasers who imply intended bodily use will have their orders cancelled and accounts permanently suspended.

What documentation is available for this compound?

Certificates of Analysis (COA) with HPLC chromatograms and Mass Spectrometry data are available for current batches. Contact our support team at support@apexlaboratory.org before ordering if your laboratory requires specific documentation to satisfy internal quality review or regulatory compliance workflows.

Is bulk ordering available?

Yes. For bulk quantities, custom packaging requirements, or recurring supply agreements, contact our team with the compound name, desired quantity, preferred dosage format, and your target delivery timeline. Volume pricing is available for qualifying orders.

Related Research Compounds

Researchers studying thymosin beta-4 fragment pathways may also be interested in related compounds available from Apex Laboratory, including BPC-157, BPC-157 + TB500 Blend, GHK-Cu. Explore our complete research catalog to browse all available peptides, reagents, and laboratory supplies, or visit our About page to learn more about our quality verification process.

Shipping, Packaging & Delivery

All orders placed before 2:00 PM Eastern Standard Time ship the same business day via tracked domestic carriers. Products are packaged in insulated, temperature-appropriate containers designed to preserve compound stability during transit. Upon delivery, transfer all materials to appropriate storage conditions immediately. For time-sensitive research protocols or special delivery requirements, contact our support team in advance to coordinate optimal shipping timing for your laboratory workflow.

Research Use Disclaimer

For in-vitro research use only. Not for human consumption. All products sold by Apex Laboratory are intended exclusively for qualified researchers, accredited laboratories, and educational institutions. Purchasers assume full responsibility for ensuring safe handling, proper storage, and compliance with all applicable federal, state, and local laws, regulations, and institutional policies governing the purchase and use of chemical research reagents.

Dosage	2mg, 5mg, 10mg