MOTS-c (Human) is a mitochondrial-derived peptide (mdp) supplied by Apex Laboratory as a high-purity research peptide intended strictly for in-vitro laboratory research and development applications.
Compound Overview
MOTS-c is a 16-amino acid peptide encoded in the mitochondrial 12S rRNA gene. It activates AMPK signaling and regulates cellular metabolism, folate-methionine cycling, and de novo purine biosynthesis. MOTS-c can translocate to the nucleus in response to metabolic stress, acting as a mitochondrial-nuclear retrograde signal.
Research Background & Published Literature
Discovered by Dr. Pinchas Cohen’s lab at USC and published in Cell Metabolism (2015). Research examines its role as a mitochondrial-encoded hormone (mitokine) regulating systemic energy homeostasis, insulin sensitivity, and exercise-responsive metabolic signaling.
Researchers interested in the published literature surrounding this compound can explore the following peer-reviewed resources for additional context on its mechanism of action, signaling pathways, and experimental applications in controlled laboratory settings:
Technical Specifications
- Product Name: MOTS-c (Human)
- Classification: Mitochondrial-Derived Peptide (MDP)
- Structural Description: 16-amino acid mitochondrial-derived peptide encoded in the 12S rRNA gene
- Molecular Weight: 2174.7 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
Storage, Handling & Stability Guidelines
Store lyophilized material at -20°C for long-term stability. After reconstitution with sterile diluent, refrigerate at 2–8°C and minimize freeze-thaw cycles by aliquoting working volumes according to your standard operating procedures.
- Minimize time at ambient temperature during handling to preserve compound integrity.
- Avoid moisture exposure by resealing vials promptly after each withdrawal.
- Use appropriate personal protective equipment and follow your institution’s chemical safety protocols at all times.
- Label all aliquots with the compound name, concentration, date of reconstitution, and operator initials for complete traceability.
Quality Assurance & Analytical Verification
Apex Laboratory applies a dual-verification quality protocol to every batch before it enters inventory. Each lot undergoes High-Performance Liquid Chromatography (HPLC) to confirm chromatographic purity and Mass Spectrometry (MS) to verify molecular identity and molecular weight. This two-step analytical process ensures that the material you receive meets our ≥99% purity standard with confirmed molecular integrity. Certificates of Analysis documenting these results are available upon request for your internal quality records.
Frequently Asked Questions
What is the primary research application of this compound?
This compound is classified as a mitochondrial-derived peptide (mdp) and is used in laboratory settings to study related signaling pathways and biological mechanisms in controlled in-vitro experiments.
What storage conditions are recommended?
For long-term storage, keep the lyophilized material at -20°C in a sealed container away from moisture and light. After reconstitution, refrigerate at 2–8°C and use within the recommended timeframe for your workflow.
Is this product approved for human use?
No. All compounds sold by Apex Laboratory are classified as chemical research reagents intended strictly for in-vitro laboratory research. They are not approved for human consumption, veterinary use, or any therapeutic application. Purchasers who imply intended bodily use will have their orders cancelled and accounts permanently suspended.
What documentation is available for this compound?
Certificates of Analysis (COA) with HPLC chromatograms and Mass Spectrometry data are available for current batches. Contact our support team at support@apexlaboratory.org before ordering if your laboratory requires specific documentation to satisfy internal quality review or regulatory compliance workflows.
Is bulk ordering available?
Yes. For bulk quantities, custom packaging requirements, or recurring supply agreements, contact our team with the compound name, desired quantity, preferred dosage format, and your target delivery timeline. Volume pricing is available for qualifying orders.
Related Research Compounds
Researchers studying mitochondrial-derived peptide (mdp) pathways may also be interested in related compounds available from Apex Laboratory, including Humanin 10mg, SS-31. Explore our complete research catalog to browse all available peptides, reagents, and laboratory supplies, or visit our About page to learn more about our quality verification process.
Shipping, Packaging & Delivery
All orders placed before 2:00 PM Eastern Standard Time ship the same business day via tracked domestic carriers. Products are packaged in insulated, temperature-appropriate containers designed to preserve compound stability during transit. Upon delivery, transfer all materials to appropriate storage conditions immediately. For time-sensitive research protocols or special delivery requirements, contact our support team in advance to coordinate optimal shipping timing for your laboratory workflow.
Research Use Disclaimer
For in-vitro research use only. Not for human consumption. All products sold by Apex Laboratory are intended exclusively for qualified researchers, accredited laboratories, and educational institutions. Purchasers assume full responsibility for ensuring safe handling, proper storage, and compliance with all applicable federal, state, and local laws, regulations, and institutional policies governing the purchase and use of chemical research reagents.
