Retatrutide is a gip/glp-1/glucagon triple receptor agonist supplied by Apex Laboratory as a high-purity research peptide intended strictly for in-vitro laboratory research and development applications.
Compound Overview
Retatrutide is a triple-acting peptide that simultaneously activates GIP, GLP-1, and glucagon receptors. This multi-receptor agonism distinguishes it from single or dual agonists currently under investigation, offering a broader metabolic research profile.
Research Background & Published Literature
Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated significant metabolic effects. Researchers studying incretin signaling, energy expenditure pathways, and hepatic lipid metabolism have shown considerable interest in this compound. Retatrutide represents a novel approach to studying the combined effects of three metabolic hormone pathways simultaneously.
Researchers interested in the published literature surrounding this compound can explore the following peer-reviewed resources for additional context on its mechanism of action, signaling pathways, and experimental applications in controlled laboratory settings:
Technical Specifications
- Product Name: Retatrutide
- Classification: GIP/GLP-1/Glucagon Triple Receptor Agonist
- Structural Description: 39-amino acid synthetic peptide
- CAS Number: 2381089-83-2
- Molecular Weight: 4471.5 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
Storage, Handling & Stability Guidelines
Lyophilized Retatrutide is stable at -20°C for extended periods. Due to its larger molecular size (39 amino acids), reconstituted aliquots should be used within 14 days when stored at 2–8°C.
- Minimize time at ambient temperature during handling to preserve compound integrity.
- Avoid moisture exposure by resealing vials promptly after each withdrawal.
- Use appropriate personal protective equipment and follow your institution’s chemical safety protocols at all times.
- Label all aliquots with the compound name, concentration, date of reconstitution, and operator initials for complete traceability.
Quality Assurance & Analytical Verification
Apex Laboratory applies a dual-verification quality protocol to every batch before it enters inventory. Each lot undergoes High-Performance Liquid Chromatography (HPLC) to confirm chromatographic purity and Mass Spectrometry (MS) to verify molecular identity and molecular weight. This two-step analytical process ensures that the material you receive meets our ≥99% purity standard with confirmed molecular integrity. Certificates of Analysis documenting these results are available upon request for your internal quality records.
Frequently Asked Questions
What makes Retatrutide different from Semaglutide or Tirzepatide?
Retatrutide is a triple receptor agonist targeting GIP, GLP-1, and glucagon receptors simultaneously, while Semaglutide targets only GLP-1 and Tirzepatide targets GIP and GLP-1. This triple mechanism provides a unique research profile for metabolic studies.
What is the molecular weight of Retatrutide?
Retatrutide has a molecular weight of approximately 4471.5 g/mol. It is a 39-amino acid synthetic peptide.
Is this product approved for human use?
No. All compounds sold by Apex Laboratory are classified as chemical research reagents intended strictly for in-vitro laboratory research. They are not approved for human consumption, veterinary use, or any therapeutic application. Purchasers who imply intended bodily use will have their orders cancelled and accounts permanently suspended.
What documentation is available for this compound?
Certificates of Analysis (COA) with HPLC chromatograms and Mass Spectrometry data are available for current batches. Contact our support team at support@apexlaboratory.org before ordering if your laboratory requires specific documentation to satisfy internal quality review or regulatory compliance workflows.
Is bulk ordering available?
Yes. For bulk quantities, custom packaging requirements, or recurring supply agreements, contact our team with the compound name, desired quantity, preferred dosage format, and your target delivery timeline. Volume pricing is available for qualifying orders.
Related Research Compounds
Researchers studying gip/glp-1/glucagon triple receptor agonist pathways may also be interested in related compounds available from Apex Laboratory, including Tirzepatide, Semaglutide, Cagrilintide. Explore our complete research catalog to browse all available peptides, reagents, and laboratory supplies, or visit our About page to learn more about our quality verification process.
Shipping, Packaging & Delivery
All orders placed before 2:00 PM Eastern Standard Time ship the same business day via tracked domestic carriers. Products are packaged in insulated, temperature-appropriate containers designed to preserve compound stability during transit. Upon delivery, transfer all materials to appropriate storage conditions immediately. For time-sensitive research protocols or special delivery requirements, contact our support team in advance to coordinate optimal shipping timing for your laboratory workflow.
Research Use Disclaimer
For in-vitro research use only. Not for human consumption. All products sold by Apex Laboratory are intended exclusively for qualified researchers, accredited laboratories, and educational institutions. Purchasers assume full responsibility for ensuring safe handling, proper storage, and compliance with all applicable federal, state, and local laws, regulations, and institutional policies governing the purchase and use of chemical research reagents.
